Hisato Kawakami, Kazuhiro Nishikawa, Toshio Shimokawa, Kazumasa Fujitani, Shigeyuki Tamura, Shunji Endo, Michiya Kobayashi, Junji Kawada, Yukinori Kurokawa, Akira Tsuburaya, Takaki Yoshikawa, Junichi Sakamoto, Taroh Satoh, for HERBIS-2, -4 and XParTS II study investigators.  The Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG) and the Epidemiological and Clinical Research Information Network (ECRIN)　　　　　　　　　　　ESMO-GI 2022, Barcelona, Spain, 29 Jun- 2 Jul 2022